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1

Crystal Engineering of the Composition of Pharmaceutical Phases: Multiple-Component Crystalline Solids Involving Carbamazepine

Fleischman, Scott G., Kuduva, Srinivasan S., McMahon, Jennifer A., Moulton, Brian, Bailey Walsh, Rosa D., Rodríguez-Hornedo, Naír, Zaworotko, Michael J.

Journal:

Crystal Growth & Design

Year:

2003

Language:

english

File:

PDF, 1.12 MB

english, 2003

2

General Principles of Pharmaceutical Solid Polymorphism. A Supramolecular Perspective

Barbara Rodriguez-Spong, Christopher P. Price, Adivaraha Jayasankar, Adam J. Matzger, Nair Rodriguez-Hornedo

Journal:

Year:

2004

File:

PDF, 51 KB

2004

3

Significance of controlling crystallization mechanisms and kinetics in pharmaceutical systems

Naír Rodríguez-hornedo, Denette Murphy

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 156 KB

english, 1999

4

Rheological Characterization of Topical Carbomer Gels Neutralized to Different pH

Mohammad T. Islam, Naír Rodríguez-Hornedo, Susan Ciotti, Chrisita Ackermann

Journal:

Pharmaceutical Research

Year:

2004

Language:

english

File:

PDF, 126 KB

english, 2004

5

A rapid thermal method for cocrystal screening

Lu, Enxian, Rodríguez-Hornedo, Naír, Suryanarayanan, Raj

Journal:

Year:

2008

Language:

english

File:

PDF, 109 KB

english, 2008

6

Reaction Crystallization of Pharmaceutical Molecular Complexes

Rodríguez-Hornedo, Naír, Nehm, Sarah J., Seefeldt, Kurt F., Pagán-Torres, Yomaira, Falkiewicz, Christopher J.

Journal:

Molecular Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 272 KB

english, 2006

7

Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

Childs, Scott L., Rodríguez-Hornedo, Naír, Reddy, L. Sreenivas, Jayasankar, Adivaraha, Maheshwari, Chinmay, McCausland, Linda, Shipplett, Rex, Stahly, Barbara C.

Journal:

Year:

2008

Language:

english

File:

PDF, 526 KB

english, 2008

8

Pharmaceutical cocrystals and poorly soluble drugs

Thakuria, Ranjit, Delori, Amit, Jones, William, Lipert, Maya P., Roy, Lilly, Rodríguez-Hornedo, Naír

Journal:

International Journal of Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 4.03 MB

english, 2013

9

pH-Dependent Solubility of Indomethacin–Saccharin and Carbamazepine–Saccharin Cocrystals in Aqueous Media

Alhalaweh, Amjad, Roy, Lilly, Rodríguez-Hornedo, Naír, Velaga, Sitaram P.

Journal:

Molecular Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 848 KB

english, 2012

10

How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

Kuminek, Gislaine, Rodriguez-Hornedo, Nair, Siedler, Sana, Rocha, Helvecio V. A., Cuffini, Silvia Lucia, Goncalves Cardoso, Simone

Journal:

Chemical Communications

Year:

2016

Language:

english

File:

PDF, 5.64 MB

english, 2016

11

An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism

Rzeczycki, Phillip, Woldemichael, Tehetina, Willmer, Andrew, Murashov, Mikhail D., Baik, Jason, Keswani, Rahul, Yoon, Gi Sang, Stringer, Kathleen A., Rodriguez-Hornedo, Nair, Rosania, Gus R.

Journal:

Pharmaceutical Research

Year:

2019

Language:

english

File:

PDF, 3.81 MB

english, 2019

12

Transformation pathways of cocrystal hydrates when coformer modulates water activity

Adivaraha Jayasankar, Lilly Roy, Naír Rodríguez-Hornedo

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 235 KB

english, 2010

13

Engineering cocrystal solubility, stability, and pHmax by micellar solubilization

Neal Huang, Naír Rodríguez-Hornedo

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 801 KB

english, 2011

14

Cocrystal Formation during Cogrinding and Storage is Mediated by Amorphous Phase

Adivaraha Jayasankar, Anongnat Somwangthanaroj, Zezhi J. Shao, Naír Rodríguez-Hornedo

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 446 KB

english, 2006

15

Effect of Initial Buffer Composition on pH Changes During Far-From-Equilibrium Freezing of Sodium Phosphate Buffer Solutions

Gerardo Gómez, Michael J Pikal, Naír Rodríguez-Hornedo

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 186 KB

english, 2001

16

Crystal Growth Kinetics of Theophylline Monohydrate

Naír Rodríguez-Hornedo, Hsiu-Jean Wu

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 1008 KB

1991

17

Growth and Morphology of L-Alanine Crystals: Influence of Additive Adsorption

David Lechuga-Ballesteros, Nair Rodriguez-Hornedo

Journal:

Pharmaceutical Research

Year:

1993

File:

PDF, 1.44 MB

1993

18

In-vitro crystallization of indinavir in the presence of ritonavir and as a function of pH

Lilian Y. Li, Naír Rodríguez-Hornedo, Tycho Heimbach, David Fleisher

Journal:

Journal of Pharmacy and Pharmacology

Year:

2003

Language:

english

File:

PDF, 322 KB

english, 2003

19

Phase transition and heterogeneous/epitaxial nucleation of hydrated and anhydrous theophylline crystals

Naír Rodríguez-Hornedo, David Lechuga-Ballesteros, Hsiu-Jean Wu

Journal:

International Journal of Pharmaceutics

Year:

1992

Language:

english

File:

PDF, 1.34 MB

english, 1992

20

The mechanism of phenytoin crystal growth

Gail L. Zipp, Naír Rodríguez-Hornedo

Journal:

International Journal of Pharmaceutics

Year:

1993

Language:

english

File:

PDF, 1.01 MB

english, 1993

21

Effects of molecular structure and growth kinetics on the morphology of l-alanine crystals

David Lechuga-Ballesteros, Nair Rodríguez-Hornedo

Journal:

International Journal of Pharmaceutics

Year:

1995

Language:

english

File:

PDF, 733 KB

english, 1995

22

The influence of additives on the growth kinetics and mechanism of l-alanine crystals

David Lechuga-Ballesteros, Naír Rodríguez-Hornedo

Journal:

International Journal of Pharmaceutics

Year:

1995

Language:

english

File:

PDF, 736 KB

english, 1995

23

Mechanisms by Which Moisture Generates Cocrystals

Jayasankar, Adivaraha, Good, David J., Rodríguez-Hornedo, Naír

Journal:

Molecular Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 330 KB

english, 2007

24

Phase Solubility Diagrams of Cocrystals Are Explained by Solubility Product and Solution Complexation

Nehm, Sarah J., Rodríguez-Spong, Barbara, Rodríguez-Hornedo, Naír

Journal:

Crystal Growth & Design

Year:

2006

Language:

english

File:

PDF, 100 KB

english, 2006

25

Tailoring aqueous solubility of a highly soluble compound via cocrystallization: effect of coformer ionization, pHmax and solute–solvent interactions

Maheshwari, Chinmay, André, Vânia, Reddy, Sreenivas, Roy, Lilly, Duarte, Teresa, Rodríguez-Hornedo, Naír

Journal:

Year:

2012

Language:

english

File:

PDF, 715 KB

english, 2012

26

Fourier transform infrared spectroscopy for the analysis of neutralizer-carbomer and surfactant-carbomer interactions in aqueous, hydroalcoholic, and anhydrous gel formulations

Mohammad T. Islam, Naír Rodríguez-Hornedo, Susan Ciotti, Chrisita Ackermann

Journal:

The AAPS Journal

Year:

2004

Language:

english

File:

PDF, 211 KB

english, 2004

27

Engineering cocrystal thermodynamic stability and eutectic points by micellar solubilization and ionization

Huang, Neal, Rodríguez-Hornedo, Naír

Journal:

Year:

2011

Language:

english

File:

PDF, 660 KB

english, 2011

28

Cocrystals: Molecular Design of Pharmaceutical Materials

Rodríguez-Hornedo, Naír

Journal:

Molecular Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 15 KB

english, 2007

29

THE EFFECT OF ADDITIVE ADSORPTION ON CRYSTAL GROWTH AND MORPHOLOGY

Lechuga-Ballesteros, David, Rodriguez-Hornedo, Nair

Journal:

Particulate Science And Technology

Year:

1992

Language:

english

File:

PDF, 198 KB

english, 1992

30

NUCLEATION AND CRYSTAL GROWTH EFFECTS ON PARTICLE CHARACTERISTICS

Rodriguez-Hornedo, Nair, Zipp, Gail, Li, Li, Lechuga-Ballesteros, David

Journal:

Particulate Science And Technology

Year:

1992

Language:

english

File:

PDF, 278 KB

english, 1992

31

Chemical Analysis of Drug Biocrystals: A Role for Counterion Transport Pathways in Intracellular Drug Disposition

Keswani, Rahul K., Baik, Jason, Yeomans, Larisa, Hitzman, Chuck, Johnson, Allison M., Pawate, Ashtamurthy S., Kenis, Paul J. A., Rodriguez-Hornedo, Nair, Stringer, Kathleen A., Rosania, Gus R.

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 2.45 MB

english, 2015

32

Cocrystal transition points: Role of cocrystal solubility, drug solubility, and solubilizing agents

Lipert, Maya P., Rodríguez-Hornedo, Naír

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 3.04 MB

english, 2015

33

Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization

Cao, Fengjuan, Amidon, Gordon L., Rodriguez-Hornedo, Nair, Amidon, Gregory E.

Journal:

Molecular Pharmaceutics

Year:

2016

Language:

english

File:

PDF, 2.50 MB

english, 2016

34

Cocrystal Solubilization in Biorelevant Media and its Prediction from Drug Solubilization

Lipert, Maya P., Roy, Lilly, Childs, Scott L., Rodríguez-Hornedo, Naír

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 570 KB

english, 2015

35

Cocrystals to facilitate delivery of poorly soluble compounds beyond-rule-of-5

Kuminek, Gislaine, Cao, Fengjuan, Bahia de Oliveira da Rocha, Alanny, Gonçalves Cardoso, Simone, Rodríguez-Hornedo, Naír

Journal:

Advanced Drug Delivery Reviews

Year:

2016

Language:

english

File:

PDF, 5.12 MB

english, 2016

36

Enhancing NMR Sensitivity of Natural-Abundance Low-γ Nuclei by Ultrafast Magic-Angle-Spinning Solid-State NMR Spectroscopy

Zhang, Rongchun, Chen, Yitian, Rodriguez-Hornedo, Nair, Ramamoorthy, Ayyalusamy

Journal:

Year:

2016

Language:

english

File:

PDF, 1.06 MB

english, 2016

37

Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties

Kaur, Ramanpreet, Cavanagh, Katie L., Rodríguez-Hornedo, Naír, Matzger, Adam J.

Journal:

Crystal Growth & Design

Year:

2017

Language:

english

File:

PDF, 1.19 MB

english, 2017

38

Mechanistic basis of cocrystal dissolution advantage

Cao, Fengjuan, Amidon, Gordon L., Rodríguez-Hornedo, Naír, Amidon, Gregory E.

Journal:

Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 2.29 MB

english, 2017

39

Understanding the differences between cocrystal and salt aqueous solubilities

Cavanagh, Katie L., Maheshwari, Chinmay, Rodríguez-Hornedo, Naír

Journal:

Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 1.46 MB

english, 2017

40

Cocrystals mitigate negative effects of high pH on solubility and dissolution of a basic drug

Chen, Yitian, Rodríguez-Hornedo, Naír

Journal:

Crystal Growth & Design

Year:

2018

Language:

english

File:

PDF, 1.18 MB

english, 2018

41

Tadalafil-malonic acid cocrystal: Physicochemical characterization, pH-solubility and supersaturation studies

Shimpi, Manishkumar R., Alhayali, Amani, Cavanagh, Katie L, Rodríguez-Hornedo, Naír, Velaga, Sitram P.

Journal:

Crystal Growth & Design

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

42

Mechanistic Analysis of Cocrystal Dissolution, Surface pH, and Dissolution Advantage as a Guide for Rational Selection

Cao, Fengjuan, Rodriguez-Hornedo, Nair, Amidon, Gregory E.

Journal:

Journal of Pharmaceutical Sciences

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

43

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

Bermejo, Marival, Kuminek, Gislaine, Al-Gousous, Jozef, Ruiz-Picazo, Alejandro, Tsume, Yasuhiro, Garcia-Arieta, Alfredo, González-Alvarez, Isabel, Hens, Bart, Amidon, Gregory, Rodriguez-Hornedo, Nair,

Journal:

Year:

2019

Language:

english

File:

PDF, 897 KB

english, 2019